• Cordycepin br S Nitrosoglutathione reductase GSNOR also iden

  2022-02-11

  

  S-Nitrosoglutathione reductase (GSNOR) also identified as glutathione-dependent formaldehyde dehydrogenase (FDH), is a zinc-dependent dehydrogenase. It is a member of the alcohol dehydrogenase (ADH) family and is called class III alcohol dehydrogenase that regulates the levels of S-nitrosothiols (

• Historically pharmacological investigations have been carrie

  2022-02-11

  

  Historically, pharmacological investigations have been carried out by first identifying a biological response to a ligand, and then subsequently using that ligand to identify the receptor(s) responsible for the response (Wilson et al., 1998). However, this approach needed revision with the discovery

• Several studies have shown that the levels

  2022-02-11

  

  Several studies have shown that the levels of reactive dicarbonyls are higher in patients with diabetes as a result of hyperglycemia.49, 50, 51 Consequently, reactive dicarbonyl-derived AGEs are elevated in plasma and accumulate in tissues prone to secondary complications, including the lens, retina

• There are also data showing

  2022-02-11

  

  There are also data showing potential beneficial effects of SGLT2i on non-alcoholic fatty liver disease (NAFLD) [[14], [15], [16], [17]], a hepatic manifestation of the metabolic syndrome that has been linked to type 2 diabetes mellitus (T2DM) development and increased cardiovascular (CV) as well as

• A number of GCK activators for treating T D

  2022-02-11

  

  A number of GCK activators for treating T2D have been developed and tested but not progressed successfully from clinical trials into therapy [45]. Our observations suggest that increased risk of hypoglycemia might be possible, particularly if drugs penetrate into brain. A further possibility is that

• br Introduction Glucose homeostasis is primarily regulated b

  2022-02-11

  

  Introduction Glucose homeostasis is primarily regulated by the hormones insulin and glucagon, secreted from the pancreatic islets of Langerhans. Although insulin produced by β Protease Inhibitor Library is the blood glucose-lowering hormone, glucagon secreted from α cells acts as the major count

• In the gastrointestinal GI tract CART expression has

  2022-02-11

  

  In the gastrointestinal (GI) tract CART expression has been described in the enteric nervous system in rats (Ekblad et al., 2003), pigs (Wierup et al., 2007), sheep (Arciszewski et al., 2009), guinea pigs (Ellis and Mawe, 2003) and humans (Kasacka et al., 2012). Less is known about CART expression i

• GLP and glucose dependent insulinotropic peptide GIP are gut

  2022-02-11

  

  GLP-1 and glucose-dependent insulinotropic peptide (GIP) are gut hormones secreted from intestinal L Trovafloxacin mesylate mg and K cells, respectively. Together, these hormones account for the vast majority of the incretin effect, the enhanced postprandial insulin secretion observed in healthy ad

• The potential therapeutic actions of GHSR in the central

  2022-02-11

  

  The potential therapeutic actions of GHSR in the central nervous system has been in the limelight lately. Peripheral administration of GHSR agonists have been shown to inhibit oxidative stress, apoptosis, proinflammatory cytokine production, microglia activation, mitochondrial dysfunction, and excit

• Some aspects of intercellular Ca wave spread

  2022-02-10

  

  Some aspects of intercellular Ca2+ wave spread are similar to the phenomenon of spreading depression and associated with migraine headache [57]. These depolarization waves, followed by electrical inhibition, are evoked by transient hypoxia and other types of resiquimod injury and spread slowly acro

• br Acknowledgments This research was

  2022-02-10

  

  Acknowledgments This research was supported by the National Institutes of Health Grants GM58442 and GM084152, as well as the National Institutes of Health Predoctoral Training Grant 5T32GM008700-13. We thank Eric Oldfield (University of Illinois, Urbana-Champaign) for providing the FDPS inhibitor

• Anti apoptotic Bcl proteins have become

  2022-02-10

  

  Anti-apoptotic Bcl-2 proteins have become attractive targets for anti-cancer agents development, because they are associated with progression of a wide variety of human cancers., , The small-molecular Bcl-2 inhibitor venetoclax (ABT-199) () has been approved recently for the treatment of patients w

• The HCV Ag immunoassay has been shown from previous studies

  2022-02-10

  

  The HCV-Ag immunoassay has been shown from previous studies to be an adequate alternative to the two-stage diagnostic process [6], [9], [16]. Kesli et al. reported a high correlation coefficient of 0.864 when comparing HCV core antigen levels with HCV RNA levels (detected using Qiagen HCV RNA test;

• It is an open question

  2022-02-10

  

  It is an open question if these in vitro findings have implications for the use of sGC activators in the in vivo situation and in patients. Assuming that incorporation in de novo synthesised enzyme occurs during therapy, one might speculate that the duration of drug administration has an influence o

• br Introduction Atherosclerosis is a chronic inflammatory

  2022-02-10

  

  Introduction Atherosclerosis is a chronic inflammatory disease characterized by lipid and leukocyte accumulation within the arterial wall. Homocysteine (Hcy) is a thiol-containing amino capmatinib derivative derived from the metabolism of dietary methionine. Epidemiological studies have shown tha

15469 records 478/1032 page Previous Next First page 上5页 476477478479480 下5页 Last page